Specifically targeted catalytic antagonists and uses thereof

Details Specifically targeted catalytic antagonists and uses thereof Specifically targeted catalytic antagonists and uses thereof

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2368213

The invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.

La présente invention concerne des molécules chimères qui sont des antagonistes catalytiques d'une molécule cible. Les antagonistes catalytiques de cette invention comprennent de préférence une fraction de ciblage fixée à une enzyme qui dégrade la molécule spécifiquement liée par la fraction cible. Les antagonistes catalytiques de cette invention se lient donc à une cible reconnue par la fraction de ciblage (par exemple, un récepteur), le composant enzymatique de la chimère dégradant ainsi tout ou partie de la cible. Ceci entraîne généralement une diminution ou une perte d'activité de la cible et la libération de la molécule chimère. La molécule chimère est alors libre d'attaquer et de dégrader une autre molécule cible.

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