Genetic silencing

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2403162

The present invention relates generally to a method of inducing, promoting or otherwise facilitating a change in the phenotype of an animal cell or group of animal cells including a animal comprising said cells. The modulation of phenotypic expression is conveniently accomplished via genotypic manipulation through such means as reducing translation of transcript to proteinaceous product. The ability to induce, promote or otherwise facilitate the silencing of expressible genetic sequences provides a means for modulating the phenotype in, for example, the medical, veterinary and the animal husbandry industries. Expressible genetic sequences contemplated by the present invention including not only genes normally resident in a particular animal cell (i.e. indigenous genes) but also genes introduced through recombinant means or through infection by pathogenic agents such as viruses.

La présente invention concerne globalement un procédé permettant d'induire, de promouvoir ou de faciliter un changement dans le phénotype d'une cellule animale ou dans un groupe de cellules animales, y compris un animal possédant lesdites cellules. La modulation de l'expression phénotypique est obtenue par manipulation du génotype par réduction de la traduction de la transcription à un produit protéique. La faculté à induire, promouvoir ou faciliter l'extinction de séquences génétiques pouvant être exprimées fournit un moyen permettant de moduler le phénotype dans, par exemple, l'industrie médicale, l'industrie vétérinaire et l'industrie d'élevage. L'invention concerne des séquences génétiques pouvant être exprimées comprenant les gènes résidant normalement dans une cellule animale particulière (c'est-à-dire des gènes indigènes) et également des gènes introduits par technique de recombinaison ou par infection par des agents pathogènes tels que des virus.

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