C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/59 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2058822
The present invention provides cephalosporins of the following general formula: (see formula I) wherein R is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, or C1-C6 haloalkyl; A and A' are taken together to form a group of the formula (see formula II) wherein X is hydrogen, halo, C1-C6 alkyl, -C1-C6 alkoxy, C1-C6 alkoxycarbonyl, amino, nitro, or carboxy; and Y is nitrogen; and pharmaceutically acceptable salts thereof. These compounds are useful as antibacterial agents. Also provided by the invention are pharmaceutical formulations incorporating a compound of the above formula as the active ingredient, and the use of such compounds as antibiotics.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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