Methods and compositions for inhibition of multi-drug...

Details Methods and compositions for inhibition of multi-drug... Methods and compositions for inhibition of multi-drug...

G - Physics

01

N

G01N 33/00 (2006.01) A01N 37/18 (2006.01) A01N 61/00 (2006.01) A61K 31/00 (2006.01) A61K 31/728 (2006.01) A61K 38/00 (2006.01) A61K 38/13 (2006.01) A61K 38/28 (2006.01) C12Q 1/00 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2513143

Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, and antibodies specific for hyaluronan receptors.

La présente invention concerne des compositions pharmaceutiques et des méthodes qui permettent de sensibiliser à des agents chimiothérapeutiques, des cellules cancéreuses qui résistent à plusieurs médicaments ou aux rayonnements. Les compositions comprennent des ligands de récepteurs du hyaluronane, y compris des glycosaminoglycanes tels que des oligomères d'hyaluronane et des dérivés de ces oligomères, des protéines de liaison de l'hyaluronane et des anticorps dirigés spécifiquement contre les récepteurs d'hyaluronane.

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