6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2492112

The present invention provides compounds of Formula (I), wherein R1 is alkyl, cycloalkyl, cycloakylalkyl, or -CH2-alkenyl, X1 is O, NH, N(alkyl), S or - C(=O), Z is N or CH; and R2 and R3 are as defined herein, pharmaceutical compositions comprising same, and methods for their use.

La présente invention concerne des composés de formule (I), dans laquelle R?1¿ est alkyle, cycloalkyle, cycloalkylalkyle ou CH¿2?-alcényle, X?1¿ est O, NH, N(alkyle), S ouC(=O), Z est N ou CH, et R?2¿ et R?3¿ sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, ainsi que des méthodes d'utilisation correspondantes.

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