A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/12 (2006.01) A61K 31/122 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2245165
The present invention relates to methods for the inhibition of the gene product of the neu oncogene, p185neu tyrosine kinase. Over-expression of the neu oncogene leads to chemoresistance. The methods disclosed involve the novel use of emodin in combination with chemotherapeutic drugs to treat carcinoma. Furthermore, emodin surprisingly potentiates the antineoplastic effects of the chemotherapeutic agents. The inventors propose that emodin sensitizes cancer cells such that they become amenable to treatment by chemotherapeutic drugs.
Méthodes d'inhibition du produit génétique du neu oncogène p185neu tyrosine kinase. La surexpression du neu oncogène conduit à la chimiorésistance. Les méthodes présentées reposent sur l'utilisation nouvelle de l'émodine en association avec des substances chimiothérapeutiques servant à traiter le carcinome. En outre, l'émodine renforce les effets antinéoplasiques des agents chimiothérapeutiques, ce qui n'était pas connu. Selon l'invention, l'émodine sensibilise les cellules cancéreuses pour les rendre sensibles aux traitements par les substances chimiothérapeutiques.
Hung Mien-Chie
Zhang Lisha
Bereskin & Parr
The Board Of Regents Of The University Of Texas System
LandOfFree
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