Treatment methods utilizing albumin-binding proteins as targets

Details Treatment methods utilizing albumin-binding proteins as targets Treatment methods utilizing albumin-binding proteins as targets

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/336 (2006.01) A61K 33/24 (2006.01)

Patent

CA 2566571

The invention provides a method for determining the response of a mammalian tumor to a chemotherapeutic agent comprising detecting and quantifying the SPARC protein in a sample isolated from the human. The invention also provides a method for delivering a chemotherapeutic agent to a tumor in a human that expresses SPARC comprising administering a pharmaceutical composition comprising the chemotherapeutic agent coupled to a compound that binds SPARC protein. The invention further provides a composition comprising a chemotherapeutic agent coupled to a compound capable of binding SPARC protein and a pharmaceutically acceptable carrier.

L'invention concerne une méthode de détermination de la réponse d'une tumeur de mammifère à un agent chimiothérapeutique, qui consiste à détecter et à quantifier la protéine SPARC dans un échantillon prélevé sur l'homme. L'invention porte également sur un procédé d'administration d'un agent chimiothérapeutique dans une tumeur chez un homme, qui exprime SPARC, procédé qui consiste à administrer une préparation pharmaceutique comprenant ledit agent chimiothérapeutique couplé à un composé qui fixe la protéine SPARC. Elle concerne encore une préparation comprenant un agent chimiothérapeutique couplé à un composé, une petite molécule, une grande molécule ou une protéine, pouvant fixer la protéine SPARC, et un véhicule acceptable au plan pharmaceutique.

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