A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/506 (2006.01) A61P 1/04 (2006.01) C07D 403/06 (2006.01)
Patent
CA 2649256
Disclosed is a therapeutic agent for inflammatory bowel disease comprising 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl- 2,4(1H,3H)-pyrimidinedione or a pharmaceutically acceptable salt thereof as an active ingredient. An effective and safe therapeutic agent for inflammatory bowel disease including ulcerative colitis and Crohn's disease can be provided. The balance between the therapeutic effect on a chronic inflammation such as inflammatory bowel disease and the adverse side effect of the compound is superior to those of an aminosalicylic acid preparation and a corticosteroid preparation. The compound shows an unexpected effect beyond a mere antidiarrheal effect.
La présente invention divulgue un agent thérapeutique pour affection abdominale inflammatoire comprenant 5-chloro-6-(2-aminopyrrolidine-1-yl)méthyle- 2,4(1H,3H)-pyrimidinedione ou un sel pharmaceutiquement acceptable de celui-ci en tant que principe actif. Un agent thérapeutique efficace et inoffensif pour les affections abdominales inflammatoires comprenant la rectocolite hémorragique et la maladie de Crohn peut être proposé. L'équilibre entre l'effet thérapeutique sur une inflammation chronique telle qu'une affection abdominale inflammatoire et l'effet indésirable du composé est supérieur à ceux d'une préparation d'acide para-aminosalicylique et d'une préparation de corticostéroïde. Le composé présente un effet inattendu au-delà d'un simple effet antidiarrhéique.
Gowling Lafleur Henderson Llp
Taiho Pharmaceutical Co. Ltd.
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