Modulation of immunostimulatory properties of short...

Details Modulation of immunostimulatory properties of short... Modulation of immunostimulatory properties of short...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2622761

Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2' sugar modifications and, optionally, internucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention.

Selon l'invention, de petits ARN interférents (petits ARNi) à double brin sont modifiés pour réduire ou éliminer leur effet immunostimulant sans affecter de façon significative leur effet de silençage génique. Les petits ARNi modifiés comprennent une ou plusieurs modifications sur la position 2' du sucre et, éventuellement, des liaisons internucléotidiques sur le brin sens. Des compositions contenant les petits ARNi modifiés et des procédés de fabrication et d'utilisation de ces petits ARNi modifiés sont présentés. De petits ARNi nouveaux et de petits ARNi caractérisés précédemment peuvent être synthétisés pour incorporer des modifications selon l'invention.

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