Cyclopentil-substituted glutaramide compounds as...

Details Cyclopentil-substituted glutaramide compounds as... Cyclopentil-substituted glutaramide compounds as...

C - Chemistry, Metallurgy

07

C

C07C 235/40 (2006.01) A61K 31/194 (2006.01) A61K 31/22 (2006.01) A61K 31/275 (2006.01) A61K 31/44 (2006.01) A61K 31/4453 (2006.01) C07C 233/63 (2006.01) C07C 255/54 (2006.01) C07D 213/30 (2006.01) C07D 295/182 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2511202

The invention relates to NEP inhibitors for treating cardiovascular disorders. Preferred NEP inhibitors are compounds of formula (I) wherein R1 is C,- C6alkyl, Ci-C6alkoxyC,~C3alkyl or C,-C6alkoxyC,-C6alkoxyC,-C3alkyl; R2 is hydrogen or C,-C6alkyl; L is a three 5 atom linkage selected from -CH2-X-CH2- and -CH2-CH2-X- where the right hand side of the linkage is attached to R3 and where X is oxygen, sulfur or methylene; R3 is phenyl or aromatic heterocyclyl, either of which may be independently substituted by one or more groups selected from: C1-C6alkyl, halo, haloC,-C6alkyl, C,-C6alkoxy, haloC1-C6alkoxy, C1-~C6alkylthio, haloC,-C6alkylthio and nitrile; and R4 and R5 are either both hydrogen, or one of R4 and R5 is hydrogen and the other is a biolabile ester- forming group that in the body of a patient is replaced by hydrogen.

L'invention concerne des inhibiteurs de l'endopeptidase neutre (NEP) destinés au traitement des troubles cardiovasculaires. Les inhibiteurs NEP préférés sont les composés représentés par la formule (I), dans laquelle R?1¿ représente alkyle C¿1?-C¿6?, alcoxy C¿1?-C¿6-?alkyle C¿1?-C¿3 ?ou alcoxy C¿1?-C¿6?,alcoxy C¿1?-C¿6?-alkyle C¿1?-C¿3?; R?2¿ représente hydrogène ou alkyle C¿1?-C¿6?; L représente une liaison à trois atomes choisie entre -CH¿2?-X-CH¿2?- et -CH¿2?-CH¿2?-X-, le côté droit de cette liaison étant rattaché à? ¿R?3¿, et X représentant oxygène, soufre ou méthylène; R?3¿ représente phényle ou hétérocyclyle aromatique, l'un ou l'autre pouvant comporter indépendamment une substitution par un ou plusieurs groupes choisis parmi: alkyle C¿1?-C¿6?, halo, halo-alkyle C¿1?-C¿6?, alcoxy C ¿1?-C¿6?, halo-alcoxy C¿1?-C¿6?, alkylthio C¿1?-C¿6?, halo-alkylthio C¿1?-C¿6? et nitrile; et R?4¿ ainsi que R?5¿ sont représentent tous deux hydrogène, ou l'un de R?4¿ et R?5¿ est hydrogène et l'autre est un groupe bioloabile formant un ester, qui est remplacé par l'hydrogène dans l'organisme du patient.

Affiliated with

Also associated with

Rating

Cyclopentil-substituted glutaramide compounds as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclopentil-substituted glutaramide compounds as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopentil-substituted glutaramide compounds as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2085795