Compositions and methods for vaccinating against hsv-2

Details Compositions and methods for vaccinating against hsv-2 Compositions and methods for vaccinating against hsv-2

C - Chemistry, Metallurgy

12

N

C12N 15/38 (2006.01) A61K 31/70 (2006.01) A61K 39/245 (2006.01) C07K 16/08 (2006.01) C12N 15/86 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2658484

The present invention relates to prophylactic and therapeutic compositions and methods for inducing an immune response to herpes simplex virus type 2 (HSV-2), in particular by introducing and expressing in a vertebrate a DNA vaccine encoding at least one of the HSV-2 proteins such as gD, VP11/12, VP 13/14 and/or VP22. Formulations based on Vaxfectin (TM) adjuvant and poloxamer were evaluated for their ability to boost the immune response to the HSV DNA vaccines.

L'invention concerne une méthode d'activation immunitaire systémique qui est efficace pour induire une réponse immunitaire systémique non spécifique de l'antigène et une réponse immunitaire forte spécifique de l'antigène chez un mammifère. La méthode est particulièrement efficace pour protéger un mammifère contre le virus herpès simplex. L'invention concerne également des compositions thérapeutiques utiles dans ladite méthode.

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