A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/05 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2408033
The invention relates to a method of treating, and improving survival in, critically ill patients, and the use of certain sterile sedative pharmaceutical compositions for the manufacture of a medicament for improving the survival of such patients; in particular such use of pharmaceutical compositions comprising a free radical scavenging sedative agent (such as propofol) and a metal ion chelating agent (such as edetate) in association with a pharmaceutically-acceptable diluent or carrier, especially such composition comprising an oil-in- water emulsion in which propofol dissolved in a water-immiscible solvent, is emulsified with water and stabilised by means of a surfactant, and which further comprises a metal ion chelating agent (such as disodium edetate).
Cette invention a trait à une méthode visant à traiter des patients gravement malades et à augmenter leurs chances de survie. Elle concerne également l'utilisation de compositions pharmaceutiques sédative stériles aux fins de la production d'un médicament destiné à augmenter ces chances de survie. Elle porte, notamment, sur l'utilisation de compositions pharmaceutiques contenant un agent sédatif phagocyte de radical libre (tel que du Propofol) et un agent chélateur d'ions métalliques (tel qu'un édétate) en association avec un diluant ou un excipient acceptable du point de vue pharmaceutique. Cette composition contient, notamment, une émulsion aqueuse dans laquelle le Propofol dissous dans un solvant non miscible dans l'eau est émulsionné avec de l'eau et stabilisé par un tensioactif, laquelle émulsion renferme, en outre, un agent chélateur d'ions métalliques, tel que de l'édétate de disodium.
Astrazeneca Ab
Fetherstonhaugh & Co.
LandOfFree
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