Modified and stabilized gdf propeptides and uses thereof

Details Modified and stabilized gdf propeptides and uses thereof Modified and stabilized gdf propeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61P 3/00 (2006.01) A61P 19/10 (2006.01) A61P 21/00 (2006.01) C07K 14/475 (2006.01) C07K 14/51 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2437218

Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasteing syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity) and bone degenerative diseases (such as osteoporosis).

La présente invention concerne des propeptides modifiés et stabilisés de protéines de facteur de différentiation de croissance, tels que GDF-8 et la protéine-11 morphogénétique osseuse. Cette invention concerne aussi des techniques de préparation et d'utilisation de ces propeptides modifiés destinés à prévenir ou à traiter des pathologies chez l'homme ou l'animal pour lesquels une augmentation des tissus musculaires pourrait être bénéfique. Ces pathologies comprennent les pathologies musculaires ou neuromusculaires (telles que la sclérose latérale amyotrophique, la dystrophie musculaire, atrophie musculaire, les maladies respiratoires obstructives et congestives, le syndrome de l'amyotrophie, la sarcopénie ou la cachexie), les maladies ou les pathologies du métabolisme ( telles que le diabète de type 2, le diabète sucré non insulino-dépendant, l'hyperglycémie ou l'obésité), les pathologies du tissu adipeux (telles que l'obésité) et les maladies dégénératives osseuses (telles que l'ostéoporose).

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