A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4355 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2481499
Pharmaceutical compositions containing cyclopamine enable the skin cells displaying inhibited cellular differentiation to overcome that inhibition. Such compositions are effective in treatment of diseases associated with impaired cellular differentiation. In tumors, induction of the differentiation of tumor cells by cyclopamine is accompanied commonly by the apoptosis of tumor cells, adding thereby to the therapeutic effectiveness. Effectiveness of cyclopamine in the treatment of psoriasis, a common disease associated with the impairment of cellular differentiation is enhanced significantly by using compositions comprising of cyclopamine and a corticosteroid
Cette invention concerne des compositions pharmaceutiques contenant de la cyclopamine et permettant aux cellules cutanées présentant une différenciation cellulaire inhibée de contrer cette inhibition. Ces compositions servent à traiter des maladies associées à un trouble de la différenciation cellulaire. Dans les tumeurs, l'induction de la différenciation de cellules tumorales par la cyplopamine est couramment accompagnée de l'apoptose de cellules tumorales, ce qui renforce l'efficacité thérapeutique. L'efficacité de la cyclopamine dans le traitement du psoriasis, qui est une maladie courante associée au trouble de la différenciation cellulaire, est renforcée considérablement par l'utilisation de compositions renfermant de la cyclopamine et un corticostéroïde.
Avci Oktay
Tas Sinan
Borden Ladner Gervais Llp
Tas Sinan
LandOfFree
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