Biomarkers for anti-nogo-a antibody treatment in spinal cord...

Details Biomarkers for anti-nogo-a antibody treatment in spinal cord... Biomarkers for anti-nogo-a antibody treatment in spinal cord...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2627966

This disclosure of this invention confirms, at the level of gene expression, the injured spinal cord and motor cortex as the primary sites of action of the anti-Nogo-A antibody treatment applied intra thecally. The disclosure further provides methods for monitoring the response of a subject to a medicament comprising an anti-Nogo-A antibody by assessing the expression of at least one gene selected from Cadherin 2, 8, 11 or 22; Ephrin A3 or B2,- Eph receptor A3 of A4; Semaphorin 4A, 4D, 4F, 6A or 6B; Plexin B2; Capping protein (actin filament, gelsolin-like); Casein kinase 1 delta; Centractin; Gelsolin; Microtubule-associated protein tau; Neurofilament 68; Myocilin; Olfactomedin 1 or 3; Interferon gamma; Rho-GDP-dissociation inhibitor 1; Dihydropyrimidinase related protein (CRMP) 1, 2 or 5; Synuclein; Amyloid beta (A4) PP-binding A1; Amyloid beta (A4) precursor-like protein 1 or 2; Prostaglandin E synthase; Benzodiazepine receptor or Biglycan.

La présente invention confirme, au niveau de l'expression génique, que la moelle épinière lésée et le cortex moteur sont les sites principaux d'action du traitement aux anticorps anti-Nogo-A appliqué par voie intrathécale. La description propose en outre des procédés pour prévoir la réponse d'un sujet à un médicament comprenant un anticorps anti-Nogo-A.

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