Method of treating or preventing tissue deterioration,...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 38/04 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2616521

A method of treatment for treating, preventing, inhibiting or reducing tissue deterioration, injury or damage due to congestive heart failure disease, or for restoring tissue adversely affected by said disease, in a subject, includes administering to a subject an effective amount of a composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a peptide agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, in the tissue.

La présente invention se rapporte à une méthode permettant de traiter, de prévenir, d'inhiber ou de réduire la détérioration, les lésions ou les dommages tissulaires causés par l'insuffisance cardiaque congestive, ou de restaurer un tissu atteint par ladite maladie, chez un sujet. La méthode selon l'invention consiste à administrer à un sujet, dans un tel tissu, une dose efficace d'une composition contenant un agent peptidique renfermant une séquence d'acides aminés LKKTET ou LKKTNT, une variante conservatrice d'un tel agent, ou un agent peptidique qui stimule la production d'un peptide LKKTET ou LKKTNT, ou une variante conservatrice d'un tel agent.

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