A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/20 (2006.01) A61K 31/23 (2006.01) A61K 31/4433 (2006.01)
Patent
CA 2294031
The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 by weight (diglyceride:monoglyceride) wherein the diglyceride and monoglyceride are mono- or di-unsaturated fatty acid esters of glycerol having sixteen to twenty-two carbon chain length, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic compounds.
La présente invention concerne une nouvelle composition pharmaceutique basée sur l'utilisation d'une phase huileuse, cette composition renfermant: un agent lipophile pharmaceutiquement actif; un mélange de diglycéride et de monoglycéride présentant un rapport variant environ entre 9:1 et 6:4 en poids (diglycéride:monoglycéride), le diglycéride et le monoglycéride étant des esters d'acides gras de glycérol mono-insaturés ou di-insaturés, de longueur de chaîne de seize à vingt-deux atomes de carbone; un ou plusieurs solvants pharmaceutiquement acceptables; et un ou plusieurs tensioactifs pharmaceutiquement acceptables. Cette composition se présente sous la forme d'une formulation autoémulsifiante, présentant une concentration élevée en composés lipophiles et une biodisponibilité orale importante pour ces derniers.
Gao Ping
Morozowich Walter
Boehringer Ingelheim International Gmbh
Macrae & Co.
Pharmacia & Upjohn Company
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