Methods of treating inflammatory and autoimmune diseases...

A - Human Necessities – 61 – K

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A61K 31/505 (2006.01) A61K 31/166 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/506 (2006.01) A61K 31/675 (2006.01) A61K 31/7068 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61K 49/06 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2641160

Alpha 4 inhibitors are used in treatment of inflammatory and autoimmune diseases, such as multiple sclerosis, Crohn's Disease, rheumatoid arthritis and asthma. Rare occurrences of progressive multifocal leucoencephalopathy during treatment with an alpha-4 agent suggest the possibility that it may be related to such treatment. Monitoring for the JC virus and educating caregivers and patients about the manifestations of progressive multifocal leucoencephalopathy can improve the safety of alpha 4 inhibitor therapy.

Les inhibiteurs alpha-4 selon l'invention sont utilisés dans le traitement de maladies inflammatoires et auto-immunes, telles que la sclérose en plaques, la maladie de Crohn, la polyarthrite rhumatoïde et l'asthme. De rares cas de leucoencéphalopathie multifocale progressive durant le traitement avec un agent alpha-4 suggèrent un lien avec ce traitement. La surveillance du virus JC et l'information du personnel soignant et des patients concernant les manifestations de leucoencéphalopathie multifocale progressive peuvent améliorer l'innocuité de la thérapie à base d'inhibiteur alpha-4.

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