Computational method for designing chemical structures...

G - Physics – 06 – F

Patent

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G06F 17/50 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2247391

The present invention relates to computational methods for designing chemical structures sharing common useful, functional properties based on specific combinations of steric configuration and binding affinity. More particularly the present invention provides a method for producing computer-simulated receptors which functionally mimic biological receptors. The simulated receptors are designed to exhibit optimized selective affinity for known target molecules. Chemical structures are then generated and evolved to exhibit selective affinity for the simulated receptors.

La présente invention concerne un procédé informatique de conception de structures chimiques ayant en commun des caractéristiques fonctionnelles, et ce, à partir de combinaisons de leur configuration stérique et de leur affinité à se lier. L'invention concerne plus spécifiquement un procédé de production de récepteurs simulés informatiquement et qui imitent fonctionnellement des récepteurs biologiques. Les récepteurs simulés sont conçus pour faire preuve d'une affinité sélective optimisée pour des molécules cibles connues. Le procédé consiste ensuite à générer les structures sélectives et à les faire évoluer de façon qu'elles fassent preuve d'une affinité sélective pour les récepteurs simulés.

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