C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/5355 (2006.01) A61P 3/00 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2729998
This invention relates to novel compounds of the Formula (I), (Ia1-10) (Ib1- 10) (Ic10), (Id1-7), (Ie1-5) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11.beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
La présente invention concerne de nouveaux composés de formule (I), (Ia1-10), (Ib1-10), (Ic1-10), (Id1-7), (Ie1-5), des sels pharmaceutiquement acceptables de ceux-ci, et des compositions pharmaceutiques de ceux-ci, qui sont utiles dans le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de 11ß-HSD1 chez des mammifères. L'invention concerne en outre des compositions pharmaceutiques de ces nouveaux composés et des procédés relatifs à leur utilisation dans la diminution ou la régulation de la production de cortisol dans une cellule, ou dans l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Eckhardt Matthias
Hamilton Bradford S.
Himmelsbach Frank
Schuler-Metz Annette
Zhuang Linghang
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
Vitae Pharmaceuticals Inc.
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