Therapeutic agents

Details Therapeutic agents Therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 491/052 (2006.01) A61K 31/415 (2006.01) C07D 231/20 (2006.01) C07D 231/22 (2006.01) C07D 405/06 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2074816

2074816 9112255 PCTABS00006 Compounds of formula (I), in which R1 represents hydrogen, cyano, C2-6 alkanoyl, C2-6 alkoxycarbonyl, CONH2, or R1 represents C1-6 alkyl or C2-6 alkenyl both of which may be substituted by cyano, halo, trifluoromethyl, hydroxy, benzoyl, C2-6 alkanoyloxy, C3-8 cycloalkoxycarbonyl, a 5-7 membered non-aromatic heterocyclic group containing 2 oxygen heteroatoms, CONR9R9', phenoxy or C1-6 alkoxy, in which C1-6 alkoxy may be further substituted by halo, hydroxy, C1-6 alkoxy or C2-6 alkanoyloxy; R2 represents hydrogen or chloro; R3 represents chloro or trifluoromethyl; or R2 and R3 are joined to form a fused benz ring; R4 represents hydrogen, C1-6 alkyl, C1-6 alkoxy or halo; R9 and R9', which may be the same or different represent hydrogen, C1-6 alkyl or benzyl, for use as immunomodulatory agents.

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