Process for preparing 1-substituted 4-cyano-1,2,3-triazoles

Details Process for preparing 1-substituted 4-cyano-1,2,3-triazoles Process for preparing 1-substituted 4-cyano-1,2,3-triazoles

C - Chemistry, Metallurgy

07

D

C07D 249/04 (2006.01) A61K 31/4192 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/02 (2006.01) C07D 403/04 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01)

Patent

CA 2260065

A process for the preparation of a compound of formula (I) in which R1 is an aromatic or heteroaromatic radical, aromatic-aliphatic or heteroaromatic- aliphatic radical, a heterocyclic radical, a cycloaliphatic radical, a cycloaliphatic-aliphatic radical or an aliphatic radical, which comprises reacting a compound of the formula (Ia) R1- N3 in which R1 is defined as indicated above, with the compound of formula (Ib) in a two-phase system. 4-Cyano-1-(2,6-difluorobenzyl)-1H-1,2,3-triazole is novel.

L'invention a pour objet un procédé de préparation d'un composé de formule (I), où R1 est un radical aromatique ou hétéroaromatique, aromatique-aliphatique ou hétéroaromatique-aliphatique, hétérocyclique, cycloaliphatique, cycloaliphatique-aliphatique ou aliphatique, comprenant la réaction d'un composé de la formule (Ia) R1-N3, où R1 est défini comme il est indiqué plus haut, avec le composé de formule (Ib), dans un système à deux phases. Le 4-cyano-1-(2,6-difluorobenzyle)-1H-1,2,3-triazole est une nouveauté.

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