A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/09 (2006.01) A61K 9/19 (2006.01) A61K 38/25 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/22 (2006.01) A61K 47/10 (2006.01)
Patent
CA 2291765
Pharmaceutical compositions are described, which comprise: a) a peptide poorly soluble in aqueous physiological saline solution, as active ingredient; b) a non-ionic aromatic hydrotropic pharmaceutically acceptable agent; and c) a physiological aqueous solution wherein the peptide (a) is an LHRH analogue or a GRF peptide, and wherein the non-ionic aromatic hydrotropic agent (2) is selected from the group consisting of: nicotinamide, nicotinic acid, benzoic acid, salicyclic acid, gentisic acid, ascorbic acid, histidine, tryptophan, phenylalanine, tyrosine, cresol, phenol, xanthines, pyridoxine, folic acid, saccharin, as well as non-ionic derivatives thereof.
L'invention concerne une composition pharmaceutique. Cette dernière comprend a) un peptide faiblement soluble dans un sérum physiologique aqueux, comme ingrédient actif; b) un agent hydrotropique aromatique non ionique, pharmaceutiquement acceptable et c) un sérum physiologique aqueux dans lequel le peptide (a) est un analogue de l'hormone libérant l'hormone lutéinisante ou un peptide GRF et où l'agent hydrotropique aromatique non ionique (2) est choisi parmi de la nicotinamide, de l'acide nicotinique, de l'acide benzoïque, de l'acide salicyclique, de l'acide gentisique, de l'acide ascorbique, de l'histidine, du tryptophane, du phénylalanine, de la tyrosine, du crésol, du phénol, des xanthines, de la pyridoxine, de l'acide folique, de la saccharine, ainsi que des dérivés non ioniques de ces derniers.
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
LandOfFree
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