Production of aldehyde-treated allergen-containing substances

Details Production of aldehyde-treated allergen-containing substances Production of aldehyde-treated allergen-containing substances

A - Human Necessities

61

K

167/129

A61K 39/35 (2006.01)

Patent

CA 1122525

ABSTRACT OF THE DISCLOSURE This invention relates to an improved method of production of formaldehyde, and lower saturated aliphatic dialdehyde-treated allergens suitable for the immunotherapy (desensitization) of individuals suffering from allergies of the immediate type in a plurality of steps wherein said formaldehyde and/or said dialdehyde is utilized alone or in combination for the modification of allergen-containing materials. These lower saturated aliphatic mono- and dialdehyde treated allergen- containing materials are useful in ameliorating the symptoms of allergic (atopic) people. Also, they are able to induce formation of blocking antibody in mammals which cross-reacts with the native allergen-containing materials. Reactions with formaldehyde are carried out in a non-phenolic environment in a plurality of steps. The reaction involving combinations of aldehydes can be carried out in a single step.

336952

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