Mice ascitic fluid (euglobulin) in immunoassay

Details Mice ascitic fluid (euglobulin) in immunoassay Mice ascitic fluid (euglobulin) in immunoassay

G - Physics

01

N

167/45

G01N 33/564 (2006.01) G01N 33/53 (2006.01)

Patent

CA 1127078

- 1 - ABSTRACT OF THE DISCLOSURE A liquid, particularly but not exclusively a liquid of human origin such as blood serum or urine, is immunoassayed for antibodies, antigens or antibody: antigen complexes, using as a reagent in the analysis an active fraction from mouse ascitic fluid. This active fraction is a euglobulin and has the ability, like human C1q, to combine with antibody:antigen complexes but not with free antibody or antigen. Unlike human C1q, however, it remains active at high pH's and its activity is not destroyed by 0.1M putrescine or 0.1M hydrazine, so analyses on human body fluids can be carried out at high pH's or in the presence of putrescine and hydrazine, without interference from endogenous human C1q. The active fraction is a very broadly applicable reagent in immunoassays and particularly useful in techniques involving agglutination of latex particles.

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