Pharmaceutical compositions and their use in the prophylaxis...

Details Pharmaceutical compositions and their use in the prophylaxis... Pharmaceutical compositions and their use in the prophylaxis...

A - Human Necessities

61

K

167/163

A61K 9/00 (2006.01) A61K 47/00 (2006.01) A61K 47/14 (2006.01) A61K 47/20 (2006.01)

Patent

CA 1115638

Abstract of the disclosure The invention relates to a solvent vehicle for therapeutics comprising a dialkyl ester of adipic acid and, optionally, DMSO, which is particularly useful for therapeutic materials having a low solubility or being insoluble in water. The invention further relates to pharmaceu?ical compositions which are suitable for parenteral administration, especially by intramuscular injection, comprising a therapeutically active material dissolved in said solvent vehicle. Solvent vehicles containing di-n-butyl adipate and DMSO and, if desired, one or more adjuvants, are preferred, Particularly useful are pharmaceutical compositions for the prophylaxis and/or treatment of diseases caused by internal parasites, which can be administered by intramuscular injection. A preferred embodiment of the invention is an injectable com- position against distomatosis (liver fluke disease) containing proportionally 12.5 g 4,6'-dichloro-4',6-dinitro-2,2'-methylene- diphenol and 30 g of DMSO, completed with di-n-butyl adipate to 100 cm3.

319844

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