Process for the production of bis(heterocyclicalkyl)...

Details Process for the production of bis(heterocyclicalkyl)... Process for the production of bis(heterocyclicalkyl)...

C - Chemistry, Metallurgy

07

D

260/300, 260/279

C07D 233/64 (2006.01) C07D 213/32 (2006.01) C07D 213/65 (2006.01) C07D 233/54 (2006.01) C07D 233/68 (2006.01) C07D 249/08 (2006.01) C07D 261/08 (2006.01) C07D 263/46 (2006.01) C07D 275/02 (2006.01) C07D 277/22 (2006.01) C07D 277/26 (2006.01) C07D 285/135 (2006.01)

Patent

CA 1049524

ABSTRACT OF THE DISCLOSURE Pharmacologically active compounds are disclosed having the following structural formula: Image wherein R1 and R2, which may be the same or different, each represent a grouping of the formula: Het - (CH2)m Z (CH2)n wherein Het is a nttrogen containing 5 or 6 membered hetero- cyclic ring, which ring is optionally substituted by lower alkyl, hydroxyl, halogen or amino; Z is sulphur or a methylene group; m is 0,1 0 or 2 and n is 2 or 3 provided that the sum of m and n is from 2 to 4; and X is sulphur, oxygen or N-Y wherein Y is hydrogen, cyano, CONH2 or SO2R3 wherein R3 is lower alkyl or aryl; provided that, when X is NH, R1 and/or R2 is such that Z is sulphur. These compounds have been found to have pharmacological activity in the animal body as antagonists to certain actions of histamine which are not blocked by "antihistamines" such as mepyramine.

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