Dialdehyde treatment of tetanus toxin and derivative obtained

Details Dialdehyde treatment of tetanus toxin and derivative obtained Dialdehyde treatment of tetanus toxin and derivative obtained

A - Human Necessities

61

K

167/135

A61K 39/08 (2006.01)

Patent

CA 1066621

DIALDEHYDE TREATMENT OF TETANUS TOXIN AND DERIVATIVE OBTAINED Abstract of the Disclosure The present invention relates to derivatives: of tetanus toxin, a process for their preparation by treating an aqueous solution of tetanus toxin with an aliphatic mono- or dialdehyde, reacting the toxin before or after the aldehyde treatment in the presence of a compound reducing disulfide bridges with a denaturing agent, obtaining the derivative of the light chain in the presence of the denaturing agent by way of protein- chemical isolation processes and suitably separating it from the denaturing agent, and compositions containing them. The products of the invention are useful in the preparation of tetanus vaccines.

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