Process for crystalline sodium cefamandole

Details Process for crystalline sodium cefamandole Process for crystalline sodium cefamandole

C - Chemistry, Metallurgy

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C07D 501/36 (2006.01) A61K 31/54 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/12 (2006.01) C07D 501/28 (2006.01) C07D 501/44 (2006.01) C07D 501/52 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1122974

X-4971 -11- Abstract A process for preparing the methanolate crystalline form of sodium cefamandole which comprises the steps a) mixing at a temperature between about 20°C. and about 30°C. a suspension of sodium O- formylcefamandole in methyl alcohol having a ratio of about one gram of sodium O-formylcefamandole for between about 2.5 ml. and about 3.5 ml. of methyl alcohol, said suspension containing between about 1.5 percent and about 3 percent by volume of water, with a concentrated solution of sodium hydroxide in methyl alcohol in an amount corresponding to about 1 ml. of said concentrated solution per gram of sodium O- formylcefamandole in said suspension, and b) separating the crystalline sodium cefamandole methanolate from the suspension.

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