A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
150/11, 167/114
A61K 35/16 (2006.01) G01N 33/48 (2006.01) G01N 33/483 (2006.01) G01N 33/96 (2006.01)
Patent
CA 1106759
Abstract of the Disclosure A process for making a biological composition for use as a blood serum reference composition in diagnostic analysis. The process comprises: (a) adding calcium to citrated plasma and mixing well to form decitrated plasma; (b) adding thrombin to the decitrated plasma and mix- ing well to form a clot of fibrin; (c) performing at least one freeze-thaw routine on the clot to cause the fibrin to contract; (d) removing the fibrin to thereby obtain serum; (e) molecular washing and ultrafiltering the serum and thereby obtaining concentrated serum; and (f) adding to the concentrated serum at least one al- kylene polyol having from 2-5 carbon atoms in an amount such that said composition's non-biological component comprises from about 40 to about 85 weight percent water And from about 15 to about 60 weight percent of said alkylene polyol. - 10 -
331130
Beckman Instruments Inc.
Macrae & Co.
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