N-9,10,dihydrolysergyl-m-amino-benzoic acid amide derivatives

Details N-9,10,dihydrolysergyl-m-amino-benzoic acid amide derivatives N-9,10,dihydrolysergyl-m-amino-benzoic acid amide derivatives

C - Chemistry, Metallurgy

07

D

260/206.5

C07D 457/06 (2006.01)

Patent

CA 1105008

Case 100-4731 N-9,10,DIHYDROLYSERGYL-M-AMINO-BENZOIC ACID AMIDE DERIVATIVES Abstract of the disclosure: The present invention provides compounds of formula I, Image I wherein X is hydrogen, chlorine or bromine and Y is hydrogen or bromine, with the proviso that when X is chlorine Y is hydrogen, Z is carbonyl or sulphonyl, R1 is alkyl of 1 to 4 carbon atoms, and either (i) R2 is hydrogen or alkyl of 1 to 5 carbon atoms, and R3 is hydrogen, alkyl of 1 to 5 carbon atoms, or phenyl, or (ii) R2 together with R3 is a radical of formula Image 100-4731 wherein R4, R5, R6 and R7 are, independ- ently, hydrogen or alkyl of 1 to 4 carbon atoms, or (iii) R2 together with R4 is a radical of formula -(CH2)2-A-(CH2)2- wherein A is a bond, oxygen, sulphur or NR8 wherein R8 is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or alkoxyphenyl, useful as venotonising agents.

295744

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