Active derivatives of methylamine, therapeutic compositions...

Details Active derivatives of methylamine, therapeutic compositions... Active derivatives of methylamine, therapeutic compositions...

C - Chemistry, Metallurgy

07

D

260/606, 260/335

C07D 295/02 (2006.01) C07C 87/02 (1980.01) C07C 91/06 (1980.01)

Patent

CA 1078837

ABSTRACT OF THE DISCLOSURE: n-Butylamine derivatives having the general formula: Image I and the pharmaceutically acceptable acid addition salts thereof wherein R4 represents hydrogen, propargyl or 2-hydroxyethyl, R5 represents methyl, propargyl, 2-hydroxyethyl, 3-hydroxy-n- propyl or R4 and R5, when they are taken together, represent methylene, ethylene, trimethylene, ethylidene or -CH2-CH2-O- CH2-CH2- and R2 is such that : - when R4 repsesents hydrogen and R5 represents methyl, R2 represents n-propyl, isopropyl, isobutyl or allyl - when R4 represents hydrogen and R5 represents propargyl, 2-hydroxyethyl or 3-hydroxy-n-propyl or when R4 and R5 are identical and each represent propargyl or 2-hydroxyethyl or when R4 and R5 are taken together and represent methylene, ethylene, trimethylene, ethylidene or -CH2-CH2-O-CH2-CH2-, then R2 represents n-propyl. These derivatives present central noradrenergic and central dopaminergic properties which make them useful in treating Parkinson's desease as well as for correcting extra- pyramidal disturbances provoked by neuroleptics.

338050

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