Tripeptide derivatives with central nervous system activity...

Details Tripeptide derivatives with central nervous system activity... Tripeptide derivatives with central nervous system activity...

C - Chemistry, Metallurgy

07

C

530/5.08

C07C 103/52 (1980.01)

Patent

CA 1059995

TRIPEPTIDE DERIVATIVES WITH CENTRAL NERVOUS SYSTEM ACTIVITY AND PREPARATION THEREOF Abstract of the Disclosure The tripeptide derivatives of formula I H-L-Pro-N(R1)CH(R2)CO-Y-R3 (I) in which R1 is hydrogen, lower alkyl or NR4R5 wherein R4 and R5 each are lower alkyl, R2 is hydrogen or lower alkyl, R3 is amino, lower alkylamino, di(lower)alkylamino or amino- (lower)alkylamino and Y is one of the amino acid residues Gly or D-Ala with the proviso that when R1 is NR4R5 wherein R4 and R5 are as defined herein and R2 and Y are as defined herein, R3 is lower alkylamino, di(lower)alkylamino or amino- (lower)alkylamino, and a method for their preparation are disclosed. The tripeptide derivatives of formula I possess central nervous system activity and methods for their use are given. - 1 -

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