Maytansinoids, their production and use

Details Maytansinoids, their production and use Maytansinoids, their production and use

C - Chemistry, Metallurgy

07

D

260/237.1, 260/2

C07D 498/18 (2006.01)

Patent

CA 1133478

ABSTRACT OF THE DISCLOSURE Novel maytansinoids of the formula: Image wherein R is C3-10 cycloalkyl, C3-10 cycloalkenyl, phenyl or a heterocyclic group selected from the class consisting of pyridyl, pyrrolidinyl, tetrazolyl, furyl and thienyl, said cycloalkyl, cycloalkenyl, phenyl and heterocyclic group being unsubstituted or substituted by C1-4 alkyl, C1-4 alkoxy, C2-4 alkanoyl, C2-4 alkanoyloxy, C2-4 alkoxycarbonyl, halogen, nitro, cyano, trifluoromethyl, di-C1-4 alkylamino, C1-4 alkylthio, methylsulfinyl, methylsulfonyl, oxo, thi- oxo or C1-4 alkanoylamido, and A is C1-4 alkylene or a bond, provided that A means said alkylene when attached to a N atom in said heterocyclic group R, have antimitotic and antitumor activities, and are of value as medicines.

338507

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