G - Physics – 01 – N
Patent
G - Physics
01
N
73/93
G01N 1/18 (2006.01) B01D 15/08 (2006.01) G01N 30/96 (2006.01) G01N 33/66 (2006.01) G01N 30/02 (2006.01) G01N 30/60 (2006.01)
Patent
CA 1110467
ABSTRACT Methods and microcolumns to determine a numerical percentage value as a diagnostic indi- cator of the blood sugar condition of a specific person. A whole blood sample is lysed and a test sample thereof is placed on a microchromatographic column bed of ion exchange material particles. The column bed is characterized by having no cyanide therein. The column bed comprises an equilibrated suspension of particles selected from the class con- sisting of CarXH and CarYOH, where "Car" repre- sents an inert substrate for carrying ionizable groups X- providing dissociated cations H+ and ionizable groups Y+ providing anions OH-. Fractions of various hemoglobin species in the test sample are preferentially eluted or desorbed from the column bed by buffer and wash solutions character- ized by having no cyanide therein. Amounts of hemo- globin species in the eluate fractions are detec- ted and measured by spectrometric (color) analy- sis. A mathematical computation using integer factors corresponding to amounts of various hemo- globin species produces the numerical percentage value.
363487
Acuff Kenneth J.
Rosenthal Murray A.
Volk Murray E.
Isolab Inc.
Ridout & Maybee Llp
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