A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/130
A61K 39/12 (2006.01) A61K 39/42 (2006.01) C07K 16/08 (2006.01)
Patent
CA 1085292
ABSTRACT OF THE DISCLOSURE An antibody-specific solid phase immunoadsorbent is prepared by adsorptivety binding a lipid-containing viral antigen, such as hepatitis B surface antigen, to the surface of a porous glass carrier having an average pore diameter within the range of about 40-200 nm and an adsorptive surface which within the pH range of 2-8 is capable of selectively and stably binding lipid-containing materials, employing an adsorptive buffer having a pH within such range. The high adsorptive selectivity of the carrier surface for the antigen under such conditions, enables preparation of the immunoadsorbent directly from whole human plasma containing the antigen, without the necessity for prior antigen purification. The resultant immunoadsor- bent has a high complexing specificity, efficiency and capacity for the specific antibody to the bound antigen, is capable of providing reasonably high yield of the specific antibody, and is stable under the conditions re- quired for antibody-antigen complexing and dissociation, thereby rendering it highly effective for the isolation and purification of the specific antibody by affinity chroma- tography techniques. A specific application of the methods and materials described which is of particular clinical significance is in providing a relatively simple and inexpensive pro- cedure for recovering purified hepatitis B antibody from standard immune serum globulin.
290465
American National Red Cross (the)
Marks & Clerk
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