C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277.7
C07D 235/02 (2006.01) C07C 37/20 (2006.01) C07C 45/00 (2006.01) C07C 45/68 (2006.01) C07C 205/06 (2006.01) C07D 209/08 (2006.01) C07D 231/10 (2006.01) C07D 317/46 (2006.01) C07D 319/08 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)
Patent
CA 1134829
RAN 4038/4 Abstract "Imidazole derivatives" Tricyclic imidazole derivatives of the formula Image I wherein R1 signifies a 2-pyridyl group optionally substituted by lower alkyl or lower alkoxy, n signifies the number 0 or 1, R2 signifies hydrogen or lower alkyl, R3 and R4 each signify hydrogen or lower alkyl, A signifies a group of the formula -CH=CH-CH=CH- ; Image ; Image ; -(CH2)2-NH-; (a) (b) (c) (d) Image ; -O-(CH2)m-O- or -CH2-O-(CH2)2-O- ; (e) (f) (g) m signifies the number 2 or 3, R5, R6, R7 and R8 each signify hydrogen or lower alkyl and R9 signifies hydrogen and R10 signifies hydrogen or lower alkyl or R9 and R10 together signify an oxo group, but with the proviso that at least one of R3 and R4 signifies lower alkyl when A signifies a group of the formula -CH=CH-CH=CH- or -(CH2)4-, and their acid addition salts inhibit the gastric acid secretion and prevent the formation of ulcers. The compounds of formula I and their acid addition salts are novel; their manufacture is described. They can be brought into galenical administration forms, and they are suitable for use as medicaments.
384169
Krasso Anna
Ramuz Henri
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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