Vaccines from a new strain of rabies virus

A - Human Necessities – 61 – K

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A61K 39/175 (2006.01) A61K 39/205 (2006.01) A61K 39/29 (2006.01)

Patent

CA 1112167

ABSTRACT The invention relates to a new strain of rabies virus no. 675, a sample of which was deposited with the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague under number CNCTC AO 4/77, to a process for the isolation of the virus strain, to new living or inactivated cell culture vaccines prepared from this new virus strain, to processes for the preparation of novel vaccines and to methods for immunization of warm blooded animals using such vaccines. Vaccines derived from this new strain can be administered by different routes and especially non-parenterally e.g. by the oral route, they provide a full protection when administered before or after a rabies infection. Moreover the live virus vaccine does not multiply after administration and no residual virus can be detected, while the vaccines cause very rapid interferon production and other additional, unknown interfering properties e.g. cellular-mediated immunity.

295550

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