C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/325.1, 260/2
C07D 295/20 (2006.01) C07C 275/38 (2006.01) C07C 275/40 (2006.01) C07D 295/215 (2006.01) C07D 303/22 (2006.01)
Patent
CA 1061342
ABSTRACT OF THE DISCLOSURE This invention discloses a new and commercially useful process for the preparation of phenoxypropylamine derivatives of the general formula (I) Image (I) and the acid addition salts thereof wherein R is a hydrogen atom or an alkyl group and R1 is a hydrogen atom or an alkyl, cycloalkyl, aralkyl or aryl group or R and R1 together represent a divalent optionally branched hydrocarbon group, optionally substituted, R2 is a hydrogen atom or an alkyl, aralkyl or aryl group, R3 is an alkyl, hydroxyalkyl, cycloalkyl, or cyanoalkyl group and X is an oxygen atom or the group -NOR4 wherein, when X is oxygen, R2 is not hydrogen and R4 is hydrogen, a lower alkyl group or an aralkyl group. This process comprises reacting a carbonic acid or thiocarbonic acid derivative of the general formula (II) Image (II) in which Y is an alkoxy, aryloxy, aralkyloxy, alkylthio, arylthio, or aralkylthio group, with an amine of the general formula (III) Image (III) at room temperature or elevated temperature and separating the resulting compound of formula I as the free base or acid addition salt thereof.
239428
Chemie Linz Aktiengesellschaft
Na
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