3-aminoindazole-1 and 2-carboxylic acid derivatives

Details 3-aminoindazole-1 and 2-carboxylic acid derivatives 3-aminoindazole-1 and 2-carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

260/315.35

C07D 231/56 (2006.01)

Patent

CA 1059523

3-AMINOINDAZOLE-1 AND 2-CARBOXYLIC ACID DERIVATIVES Abstract 3-Aminoindazoles of the formulas Image Image and wherein Y is lower alkoxy, lower alkylamino or di(lower alkyl)amino; R is hydrogen or lower alkyl; R1 is hydrogen or lower alkyl or, when R is hydrogen, formyl; and each of R2', R2" and R2"' is selected, independently of the others, from the group consisting of hydrogen, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino, di(lower alkyl)amino, lower alkanoylamino, carbo(lower alkoxy)amino, halo, trifluoromethyl, cyano and carbo(lower alkoxy), and the pharmaceutically acceptable nontoxic salts thereof are analgesic, anti-inflannatory and antipyretic agents. The compounds, of which 3-amino-6-chloroindazole-1-carboxylic acid ethyl ester is a typical embodiment, are prepared through treatment of the appropriate 3-aminoindazole with a deriva- tive of carbonic acid or through thermal isomerization.

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