Preparation of vincamine 2-ketoglutarate

Details Preparation of vincamine 2-ketoglutarate Preparation of vincamine 2-ketoglutarate

C - Chemistry, Metallurgy

07

D

260/272

C07D 519/04 (2006.01) C07D 461/00 (2006.01)

Patent

CA 1051898

ABSTRACT OF THE DISCLOSURE The new compound vincamine 2-ketoglutarate of the formula: Image is disclosed and is prepared by mixing 2-ketoglutaric acid and vincamine or a salt thereof in a solvent and recovering the resulting vincamine 2-ketoglutarate which has interesting properties as a vasodilator and brain oxygenator. The vincamine may be prepared by allowing a mixture of a solution of 16-epivincamine and a quaternary ammonium hydroxide to stand whereafter the vincamine is recovered. - 1 -

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