C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/322, 260/363
C07D 307/58 (2006.01) C07C 45/71 (2006.01) C07C 49/84 (2006.01) C07D 207/273 (2006.01) C07D 207/38 (2006.01) C07D 307/68 (2006.01) C07F 9/40 (2006.01)
Patent
CA 1133494
ABSTRACT OF THE DISCLOSURE The present invention relates to new substituted 4-aryl- 2,5-dihydro-furane-2-ones and 4-aryl-1,5-dihydro-2H-pyrrole- 2-ones of general formula I Image (I) wherein R1 and R2, which can be equal or different, are a hydrogen or halogen atom, an alkyl- or acylamino group with 1 to 6 carbon atoms,or a carbamoylmethyl group, R3 and R4, which can be equal or different, are a hydrogen atom or a methyl group, R5 is a hydrogen atom, a dimethoxyphenyl group or an acyl- amino group of the general formula II R6-CONH- (II) wherein R6 is an alkyl group with 1 to 4 carbon atoms, and A is an oxygen atom, or an imino- or alkylimino group with 1 to 4 carbon atoms, or their physiologically acceptable acid addition salts, as well - a - as to a method for their production and their use in phramaceutic preparations. Furthermore, the present invention relates to new substi- tuted 4-aryl-2,5-dihydro-furane-2-ones and 4-aryl-1,5-dihydro-2H- pyrrole-2-ones of general formula III Image (III) wherein R1, R2 and A are as above and R7 is a hydrogen atom, a methyl- or benzyl group and the residue is Image or Image wherein X is a chlorine or bromine atom, and to a method for its production and the use of same as an intermediate product in the production of the 4-aryl-2,5-dihydro-furane-2-ones and 4-aryl-1,5-dlhydro-2H-pyrrole-2-ones of the formula I. The compounds according to the present invention, of the general formula I and their acid addition salts possess valuable therapeutic properties. They have .beta.-adrenolytic and blood pressure reducing effects and can thus be used in the treatment of angina pectoris, hypertony and arrhythmia. The dosage for human patients amounts to about 15 - 200 mg per day. _ b _
331082
Beiersdorf Aktiengesellschaft
Gowling Lafleur Henderson Llp
LandOfFree
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