Meso-ionic didehydro derivatives of 1,7-dehydro-1-...

C - Chemistry – Metallurgy – 07 – D

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260/242.01

C07D 487/14 (2006.01) C07D 231/38 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1095907

MT120b ABSTRACT MESO-IONIC DIDEHYDRO DERIVATIVES OF 1,7-DEHYDRO-1- SUBSTITUTED-3H-PYRAZOLO[4,3-e]1,2,4-TRIAZOLO[4,3-c]- PYRIMIDINE-3-THIONES AND 3-ONES New 1,7-dihydro-1-substituted-3H-pyrazolo[4,3-e]- 1,2,4-triazolo[4,3-c]pyrimidine-3-thione and 3-one mesoionic didehydro derivatives which have the formula Image wherein R1 is hydrogen, lower alkyl, phenyl-lower alkyl, cycloalkyl or hydroxy-lower alkyl; R2 is hydrogen or lower alkyl; R3 is lower alkyl, cycloalkyl or hydroxy- lower alkyl; and X is sulfur or oxygen, are useful as anti-inflammatory agents.

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