C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/552, 260/479
C07D 307/66 (2006.01) C07D 307/52 (2006.01) C07D 307/73 (2006.01)
Patent
CA 1058195
ABSTRACT OF THE DISCLOSURE New .alpha.-aminooxycarobxylic amide derivatives of the general formula (I) Image (I) wherein X represent a furfurylidene or nitro furfurylidene group or a C1-7 alkylidene or isoalkylidene group which may have at least one substituent selected from the group consist- ing of a lower alkoxycarbonyl group or, a phenyl group which may have at least one halogen, hydroxy amino, lower alkyl- amino, nitro or methoxy substituent; R represents hydrogen, benzyl group or a C1-5 alkyl group; R' represents hydrogen or a C1-5 alkyl group; and Y represents a lower alkyl benzyl group, a lower cycloalkyl group or a phenyl group which may have at least one halogen and/or methoxy substituent are prepared, for example, by reacting an .alpha.-aminooxycarboxylic amide derivative of the general formula (II) or an acid addition salt thereof Image (II) wherein R, R' and Y have the above meanings, with an oxo com- pound of the general formula (III) X = O (III) wherein X has the above meaning. Compounds of the general formula I posses tuberculostatic properties and can be used for the treatment of tuberculosis.
214946
Dancsi Lajos
Fekete Gyorgy
Kisfaludy Lajos
Patthy Agnes
Szabo Istvan
Na
Richter Gedeon Vegyeszeti Gyar Rt
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