Therapeutic compounds and intermediates therefor

Details Therapeutic compounds and intermediates therefor Therapeutic compounds and intermediates therefor

C - Chemistry, Metallurgy

07

D

260/239.1, 260/2

C07D 487/04 (2006.01) C07C 323/09 (2006.01) C07D 239/42 (2006.01)

Patent

CA 1051885

Abstract This invention relates to compounds of the formula Image I wherein m is 1 or 2, when m is 1, R occupies either the 4- or 5-positions of the starting 2-aminopyrimidine, but when R is halogen it occupies only position-5; whem m is 2, the two R-substituents occupy the 4- and 5-positions of the starting 2-aminopyrimidine, but only one of the two R-sub- stituents can be halogen and it must occupy the 5-position; R is the same of different and is hydrogen, F, Cl, Br, alkyl of from 1 to 4 carbons, benzyl, phenyl, or mono-substituted phenyl wherein the substituent is F, Cl, Br, I, alkyl of from 1 to 4 carbons, alkoxy of from 1 to 4 carbons, or tri- fluoromethyl; provided that when R is halogen, and m is 1, R occupies only the 5-position in the starting 2-aminopyrimidine; R' is hydrogen, F, Cl, Br, I, alkyl of from 1 to 4 carbons, alkoxy of from 1 to 4 carbons, alkylthio of from 1 to 4 carbons, alkylsulfonyl wherein the alkyl radical has from 1 to 4 carbons, phenyl, phenyloxy, sulfamoyl, dialkylamidosulfonyl wherein each alkyl radical has from 1 to 4 carbons, trifluoromethyl, mono-substituted phenyl or mono-substituted phenyloxy wherein the substituent is F, Cl, Br, I, alkyl of from 1 to 4 carbons, alkoxy of from 1 to 4 carbons or trifluoromethyl; n is 2 or 3, and pharmaceutically acceptable acid addition salts thereof, a process for preparing them and intermediates therefor. These compounds exhibit central nervous system stimulating properties and act as muscle relaxants.

203632

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