C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/518, 260/532
C07C 61/35 (2006.01) C07C 51/487 (2006.01) C07C 61/40 (2006.01)
Patent
CA 1126291
ABSTRACT A process for separating the individual optically active isomers of cis- or trans- cyclopropane carboxylic acids which comprises the step of treating an aqueous solution of a soluable salt of the racemate or diastereoisomeric mixture with just sufficient of a suitable optically active amine to cause precipi- tation of one isomer or diastereoisomer of the cyclopropane carboxylic acid as the amine salt, whilst substantially all of the other isomer (or isomers if more than two are present in the mixture) remains in solution as the soluble salt. The process can be used to separate (+)-cis-3-(2-chloro-3,3,3- trifluoroprop-1-en-lyl)-2,2-dimethylcyclopropane carboxylic acid from a (+)-cis-mixture.
338326
Imperial Chemical Industries Limited
Roussin Bernard F.
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