Process for separating optical isomers of cyclopropane...

C - Chemistry – Metallurgy – 07 – C

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260/518, 260/532

C07C 61/35 (2006.01) C07C 51/487 (2006.01) C07C 61/40 (2006.01)

Patent

CA 1126291

ABSTRACT A process for separating the individual optically active isomers of cis- or trans- cyclopropane carboxylic acids which comprises the step of treating an aqueous solution of a soluable salt of the racemate or diastereoisomeric mixture with just sufficient of a suitable optically active amine to cause precipi- tation of one isomer or diastereoisomer of the cyclopropane carboxylic acid as the amine salt, whilst substantially all of the other isomer (or isomers if more than two are present in the mixture) remains in solution as the soluble salt. The process can be used to separate (+)-cis-3-(2-chloro-3,3,3- trifluoroprop-1-en-lyl)-2,2-dimethylcyclopropane carboxylic acid from a (+)-cis-mixture.

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