Process for the racemate splitting of d,l-penicillamine

Details Process for the racemate splitting of d,l-penicillamine Process for the racemate splitting of d,l-penicillamine

C - Chemistry, Metallurgy

07

D

260/526, 260/310

C07D 277/60 (2006.01) C07D 277/06 (2006.01) C07D 499/42 (2006.01)

Patent

CA 1040205

ABSTRACT OF THE DISCLOSURE The present invention provides in the production of optical isomers of penicillamine in which a protected derivative of the penicillamine racemate is reacted with an optically active base, separating an optical isomers so formed by precipitation and splitting a separated optical isomer from said base and from the protecting group. The improvement in which the optically active base is an optical isomer of threo-1-(p-nitro-phenyl)-2-amino- propanediol-1,3 having the formula Image or a salt thereof.

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