Substituted arylalkylamines

Details Substituted arylalkylamines Substituted arylalkylamines

C - Chemistry, Metallurgy

07

D

260/321, 260/309

C07D 209/44 (2006.01) C07D 209/46 (2006.01) C07D 209/48 (2006.01) C07D 275/04 (2006.01) C07D 275/06 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1073915

ABSTRACT OF THE DISCLOSURE The invention relates to new substituted arylalkylamines which in general possess interesting pharmacological properties, in particular a heart frequency decreasing activity. These compounds are of the general formula I Image (I) wherein R1 represents a hydrogen atom, a lower alkyl group or a phenyl group; either R2 represents a hydrogen atom, chlorine atom or methoxy group and R3 represents a hydrogen atom or a methoxy group, or R2 or R3 together represent a methlenedioxy or ethylenedioxy group; R4 and R5, which may be the same of different, each represents a hydrogen atom or a lower alkyl group; either R6 represents a hydrogen atom or a lower alkoxy group and R7 represents a lower alkoxy group, or R6 and R7 together represent a methylene- dioxy or ethylenedioxy group; X represents a carbonyl or sulfonyl group; and n represents 2 or 3. Several processes for the preparation and inter- conversion of these compounds are described and exemplified. Examples of pharmaceutical compositions containing the new compounds are also given,

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