Continuous production of glucose isomerase and its use

C - Chemistry – Metallurgy – 12 – P

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195/125, 195/67

C12P 21/00 (2006.01) C12N 9/92 (2006.01)

Patent

CA 1054084

ABSTRACT OF THE DISCLOSURE A process for the continuous production of glucose isomers by maintaining a nutrient in the culture medium at a concen- tration which is limiting to growth. Preferably the growth limiting nutrient is the carbon source. The invention also covers a process for isomerizing glucose to fructose using continuously prepared glucose isomerase. Important conditions for culturing the glucose isomerase producing microorganism are the dissolved oxygen tension and dilution rate.

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