C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/239.5
C07D 487/04 (2006.01) C07D 231/14 (2006.01) C07D 231/16 (2006.01) C07D 231/38 (2006.01)
Patent
CA 1154762
Abstract Substituted pyrazolobenzodiazepinones of the general formula I Image (I) wherein R1 denotes an alkyl radical with 1 to 4 carbon atoms, R2 denotes a hydrogen atom or an alkyl radical with 1 to 4 carbon atoms, R3 denotes a hydrogen atom or the group -Co-A-R4, R4 denotes a halogen atom or the group -N(R5)R6 and R5 denotes an alkyl radical with 1 to 4 carbon atoms or an alkenyl radical with 3 to 5 carbon atoms and R6 has one of the meanings of R5 or represents the group -(CH2)m-N(R7)R8,or R5 and R6 together, and including the nitrogen atom to which they are linked, denote a morpho- lino group, a pyrrolidino group, a piperidino group, a hexahydroazepin-l-yl group, a piperazin- l-yl group which is optionally substituted in the 4-position by a methyl or ethyl group or by a benzyl group, a 2,4-dimethylpiperazin-1-yl group or a hexahydro-1H-1,4-diazepin-1-yl group which is substituted in the 4-position by a methyl or ethyl group, and R7 denotes an alkyl group with 1 to 4 carbon atoms, R8 denotes an alkyl group with 1 to 4 carbon atoms, A denotes a straight-chain or branched alkylene group with 1 to 5 carbon atoms and m denotes 2 or 3, and their acid addition salts, are new compounds, They either have a protective action on the stomach and intestines and are suitable for the treatment of dis- eases due to affections of the stomach or intestines, or they constitute intermediate products. Processes for the preparation of the new pharmacologically active compounds and of the intermediate products are given.
357500
Byk Gulden Lomberg Chemische Fabrik G.m.b.h.
Fetherstonhaugh & Co.
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